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T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching …

Optimal protein synthesis requires bases in transfer RNAs to be modified. A key modification has been shown to involve an unusual two-step mechanism that entails the sequential activities of two enzymes.  A central dogma of molecular biology is that DNA and the corresponding RNA are complementary. But this complementarity is rewired by a process called …

Cancer incidence and mortality statistics reported by the American Cancer Society1 and other resources were used to create the list. To qualify as a common cancer for the list, the estimated annual incidence for 2019 had to be 40,000 cases or more. The most common type of cancer on the list is breast cancer, with 271,270 …